Treated wastewater collaborates will multiple SDGs and support countries to achieve universal access to clean water and proper sanitation. Beyond the SDG 6, treated wastewater offers an opportunity for energy and food production and contributes to achieve the goal the targets for resilient cities. The general trend in wastewater treatment in the region has been consistently increasing. Yet, the environmental co-benefits of reducing the discharge of untreated wastewater remains unknown. Project scale wastewater plants are energy neutral and supply cities and dams with high quality water. The challenge of scaling up best practices and show cases in making treatment plants energy neutral and financially sustainable. A few flagship projects show that optimal performance of wastewater treatment plants requires a proactive policy, a conducive regulatory framework and a sound an efficient technical and financial management. The session will be a platform for Knowledge and experience exchange between countries, NGOs and private sector on ways to scale up best practices in turning the “orphan" sub-sector of wastewater treatment and reuse a performing enterprise that helps countries and regions to face water scarcity, protect the environment and create wealth and jobs in cities and suburbs.